Discovery and Optimization of Indolyl-Containing 4-Hydroxy-2-Pyridone Type II DNA Topoisomerase Inhibitors Active against Multidrug Resistant Gram-negative Bacteria-Reference-Cited by-同舟云学术

Discovery and Optimization of Indolyl-Containing 4-Hydroxy-2-Pyridone Type II DNA Topoisomerase Inhibitors Active against Multidrug Resistant Gram-negative Bacteria

Published:2018-05-04 Issue:10 Volume:61 Page:4456-4475
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Gerasyuto Aleksey I.¹,Arnold Michael A.¹^ORCID,Wang Jiashi¹,Chen Guangming¹,Zhang Xiaoyan¹,Smith Sean¹,Woll Matthew G.¹,Baird John¹,Zhang Nanjing¹,Almstead Neil G.¹,Narasimhan Jana¹,Peddi Srinivasa¹,Dumble Melissa¹,Sheedy Josephine¹,Weetall Marla¹,Branstrom Arthur A.¹,Prasad J. V. N.¹,Karp Gary M.¹

Affiliation:

1. PTC Therapeutics, Inc., 100 Corporate Court, South Plainfield, New Jersey 07080, United States

Funder

Wellcome Trust

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

http://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.8b00114

Reference48 articles.

1. Tackling antibiotic resistance

2. Centers for Disease Control and Prevention. Antibiotic resistance threats in the United States. US Department of Health and Human Services: Atlanta, GA, 2013. Available from http://www.cdc.gov/drugresistance/pdf/ar-threats-2013-508.pdf (accessed March 28, 2018).

3. The true cost of antimicrobial resistance

4. bWorld Health Organization. Antimicrobial Resistance: Global Report on Surveillance 2014; WHO: Geneva, Switzerland, 2014. Available from http://apps.who.int/iris/bitstream/10665/112642/1/9789241564748_eng.pdf (accessed March 28, 2018).

Cited by 13 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Discovery of Conformationally Constrained ALK2 Inhibitors;Journal of Medicinal Chemistry;2024-03-18

2. Pyridoxal hydrochloride thiosemicarbazones with copper ions inhibit cell division via Topo-I and Topo-IIɑ;Journal of Inorganic Biochemistry;2022-07

3. A comprehensive review on potential therapeutic inhibitors of nosocomial Acinetobacter baumannii superbugs;Bioorganic Chemistry;2022-07

4. Recent applications of seven-membered rings in drug design;Bioorganic & Medicinal Chemistry;2022-03

5. Ribonucleotide reductase, a novel drug target for gonorrhea;ELIFE;2022