Discovery of Orally Bioavailable, Quinoline-Based Aldehyde Dehydrogenase 1A1 (ALDH1A1) Inhibitors with Potent Cellular Activity-Reference-Cited by-同舟云学术

Discovery of Orally Bioavailable, Quinoline-Based Aldehyde Dehydrogenase 1A1 (ALDH1A1) Inhibitors with Potent Cellular Activity

Published:2018-05-16 Issue:11 Volume:61 Page:4883-4903
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Yang Shyh-Ming¹^ORCID,Martinez Natalia J.¹,Yasgar Adam¹,Danchik Carina¹,Johansson Catrine²,Wang Yuhong¹,Baljinnyam Bolormaa¹,Wang Amy Q.¹,Xu Xin¹,Shah Pranav¹,Cheff Dorian¹,Wang Xinran S.¹,Roth Jacob¹,Lal-Nag Madhu¹,Dunford James E.²,Oppermann Udo²,Vasiliou Vasilis³,Simeonov Anton¹,Jadhav Ajit¹,Maloney David J.¹

Affiliation:

1. National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville, Maryland 20850, United States

2. Centre for Translational Myeloma Research, Botnar Research Centre, Oxford NIHR BRU, University of Oxford, Oxford OX3 7LD, U.K.

3. Department of Environmental Health Sciences, Yale School of Public Health, 60 College Street, New Haven, Connecticut 06510, United States

Funder

National Center for Advancing Translational Sciences

Arthritis Research UK

National Institute on Alcohol Abuse and Alcoholism

Cancer Research UK

Rosetrees Foundation

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine