Sulfonamido-2-arylbenzoxazole GroEL/ES Inhibitors as Potent Antibacterials against Methicillin-Resistant Staphylococcus aureus (MRSA)

Author:

Abdeen Sanofar1,Kunkle Trent1,Salim Nilshad1,Ray Anne-Marie1,Mammadova Najiba1,Summers Corey1,Stevens Mckayla1,Ambrose Andrew J.2ORCID,Park Yangshin134,Schultz Peter G.5ORCID,Horwich Arthur L.6,Hoang Quyen Q.134,Chapman Eli2,Johnson Steven M.1ORCID

Affiliation:

1. Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, 635 Barnhill Drive, Indianapolis, Indiana 46202, United States

2. College of Pharmacy, Department of Pharmacology and Toxicology, The University of Arizona, 1703 East Mabel Street, P.O. Box 210207, Tucson, Arizona 85721, United States

3. Stark Neurosciences Research Institute, Indiana University School of Medicine, 320 West 15th Street, Suite 414, Indianapolis, Indiana 46202, United States

4. Department of Neurology, Indiana University School of Medicine, 635 Barnhill Drive, Indianapolis, Indiana 46202, United States

5. Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, United States

6. HHMI, Department of Genetics, Yale School of Medicine, Boyer Center for Molecular Medicine, 295 Congress Avenue, New Haven, Connecticut 06510, United States

Funder

Howard Hughes Medical Institute

University of Arizona

National Institute of General Medical Sciences

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Reference36 articles.

1. Tacconelli, E.; Magrini, N. Global priority list of antibiotic-resistant bacteria to guide research, discovery, and development of new antibiotics; World Health Organization: Geneva, Switzerland, 2017; p 7.

2. Centers for Disease Control and Prevention Antibiotic Resistance Threats in the United States, 2013; Centers for Disease Control and Prevention: Atlanta, Georgia, 2013; p 114.

3. Antimicrobial susceptibility of Gram-negative ESKAPE pathogens isolated from hospitalized patients with intra-abdominal and urinary tract infections in Asia–Pacific countries: SMART 2013–2015

4. Mechanisms of Antimicrobial Resistance in ESKAPE Pathogens

5. Federal Funding for the Study of Antimicrobial Resistance in Nosocomial Pathogens: No ESKAPE

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