Validation of Matrix Metalloproteinase-9 (MMP-9) as a Novel Target for Treatment of Diabetic Foot Ulcers in Humans and Discovery of a Potent and Selective Small-Molecule MMP-9 Inhibitor That Accelerates Healing-Reference-Cited by-同舟云学术

Validation of Matrix Metalloproteinase-9 (MMP-9) as a Novel Target for Treatment of Diabetic Foot Ulcers in Humans and Discovery of a Potent and Selective Small-Molecule MMP-9 Inhibitor That Accelerates Healing

Published:2018-09-13 Issue:19 Volume:61 Page:8825-8837
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Nguyen Trung T.¹,Ding Derong¹,Wolter William R.²,Pérez Rocio L.¹,Champion Matthew M.¹,Mahasenan Kiran V.¹,Hesek Dusan¹,Lee Mijoon¹^ORCID,Schroeder Valerie A.²,Jones Jeffrey I.¹,Lastochkin Elena¹,Rose Margaret K.¹,Peterson Charles E.³,Suckow Mark A.²,Mobashery Shahriar¹^ORCID,Chang Mayland¹^ORCID

Affiliation:

1. Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana 46556, United States

2. Freimann Life Sciences Center and Department of Biological Sciences, University of Notre Dame, Notre Dame, Indiana 46556, United States

3. Center for Wound Healing, Elkhart General Hospital, Elkhart, Indiana 46514, United States

Funder

American Diabetes Association

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.8b01005

Reference37 articles.

1. Global estimates of diabetes prevalence for 2013 and projections for 2035

2. National Diabetes Statistics Report, 2017. Estimates of Diabetes and Its Burden in the United States. Centers for Disease Control and Prevention, 2017.

3. Diabetic Foot Ulcers and Their Recurrence

4. A Matched Cohort Study of the Risk of Cancer in Users of Becaplermin

5. Short and Long Term Mortality Rates after a Lower Limb Amputation

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