1-[3-(4-Butylpiperidin-1-yl)propyl]-1,2,3,4-tetrahydroquinolin-2-one (77-LH-28-1) as a Model for the Rational Design of a Novel Class of Brain Penetrant Ligands with High Affinity and Selectivity for Dopamine D4 Receptor-Reference-Cited by-同舟云学术

1-[3-(4-Butylpiperidin-1-yl)propyl]-1,2,3,4-tetrahydroquinolin-2-one (77-LH-28-1) as a Model for the Rational Design of a Novel Class of Brain Penetrant Ligands with High Affinity and Selectivity for Dopamine D4 Receptor

Published:2018-03-28 Issue:8 Volume:61 Page:3712-3725
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Del Bello Fabio¹,Bonifazi Alessandro²,Giorgioni Gianfabio¹,Cifani Carlo¹,Micioni Di Bonaventura Maria Vittoria¹,Petrelli Riccardo¹,Piergentili Alessandro¹^ORCID,Fontana Stefano³,Mammoli Valerio³,Yano Hideaki²,Matucci Rosanna⁴,Vistoli Giulio⁵^ORCID,Quaglia Wilma¹

Affiliation:

1. Scuola di Scienze del Farmaco e dei Prodotti della Salute, Università di Camerino, Via S. Agostino 1, 62032 Camerino, Italy

2. Molecular Targets and Medications Discovery Branch, National Institute on Drug Abuse−Intramural Research Program, National Institutes of Health, 333 Cassell Drive, Baltimore, Maryland 21224, United States

3. Center for Drug Discovery and Development-DMPK, Aptuit, an Evotec Company, Via A. Fleming, 4, 37135 Verona, Italy

4. Dipartimento di Neuroscienze, Psicologia, Area del Farmaco e Salute del Bambino (NEUROFARBA), Sezione di Farmacologia e Tossicologia, Università degli Studi di Firenze, Viale Pieraccini 6, 50139 Firenze, Italy

5. Dipartimento di Scienze Farmaceutiche, Università degli Studi di Milano, Via Mangiagalli 25, 20133 Milano, Italy

Funder

National Institute on Drug Abuse

Fondo di Ateneo per la Ricerca, Universit? degli Studi di Camerino

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.8b00265

Reference52 articles.

1. Molecular properties of muscarinic acetylcholine receptors