Conversion of Quinazoline Modulators from Inhibitors to Activators of β-Glucocerebrosidase-Reference-Cited by-同舟云学术

Conversion of Quinazoline Modulators from Inhibitors to Activators of β-Glucocerebrosidase

Published:2019-01-15 Issue:3 Volume:62 Page:1218-1230
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Zheng Jianbin¹²,Jeon Sohee²,Jiang Weilan²,Burbulla Lena F.²,Ysselstein Daniel²,Oevel Kristine²,Krainc Dimitri²^ORCID,Silverman Richard B.¹^ORCID

Affiliation:

1. Department of Chemistry, Chemistry of Life Processes Institute, Center for Molecular Innovation and Drug Discovery, and Center for Developmental Therapeutics, Northwestern University, Evanston, Illinois 60208, United States

2. Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, United States

Funder

National Institute of Neurological Disorders and Stroke

Michael J. Fox Foundation for Parkinson's Research

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.8b01294

Reference26 articles.

1. Mutations in the Glucocerebrosidase Gene and Parkinson's Disease in Ashkenazi Jews

2. Multicenter Analysis of Glucocerebrosidase Mutations in Parkinson's Disease

3. Slowing of neurodegeneration in Parkinson's disease and Huntington's disease: future therapeutic perspectives

4. The link between the GBA gene and parkinsonism

5. Genetics and genomics of Parkinson’s disease

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