Structure Overhaul Affords a Potent Purine PI3Kδ Inhibitor with Improved Tolerability-Reference-Cited by-同舟云学术

Structure Overhaul Affords a Potent Purine PI3Kδ Inhibitor with Improved Tolerability

Published:2019-04-15 Issue:9 Volume:62 Page:4370-4382
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Methot Joey L.^ORCID,Zhou Hua,Kattar Sam D.,McGowan Meredeth A.,Wilson Kevin,Garcia Yudith,Deng Yongi,Altman Michael,Fradera Xavier^ORCID,Lesburg Charles,Fischmann Thierry,Li Chaomin,Alves Steve,Shah Sanjiv,Fernandez Rafael,Goldenblatt Peter,Hill Armetta,Shaffer Lynsey,Chen Dapeng,Tong Vince,McLeod Robbie L.,Yu Hongshi,Bass Alan,Kemper Ray,Gatto Nicholas T.,LaFranco-Scheuch Lisa,Trotter Benjamin Wesley,Guzi Timothy,Katz Jason D.

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.8b01818

Reference56 articles.

1. Phosphoinositides in cell regulation and membrane dynamics

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4. PI3K inhibitors in inflammation, autoimmunity and cancer

5. Inhibition of PI3Kδ Reduces Kidney Infiltration by Macrophages and Ameliorates Systemic Lupus in the Mouse

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