Identification of Selective Acyl Sulfonamide–Cycloalkylether Inhibitors of the Voltage-Gated Sodium Channel (NaV) 1.7 with Potent Analgesic Activity-Reference-Cited by-同舟云学术

Identification of Selective Acyl Sulfonamide–Cycloalkylether Inhibitors of the Voltage-Gated Sodium Channel (NaV) 1.7 with Potent Analgesic Activity

Published:2018-11-30 Issue:2 Volume:62 Page:908-927
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Sun Shaoyi¹,Jia Qi¹,Zenova Alla Y.¹,Wilson Michael S.¹,Chowdhury Sultan¹,Focken Thilo¹^ORCID,Li Jun²,Decker Shannon¹,Grimwood Michael E.¹,Andrez Jean-Christophe¹,Hemeon Ivan¹,Sheng Tao¹,Chen Chien-An³,White Andy³,Hackos David H.²,Deng Lunbin²,Bankar Girish¹,Khakh Kuldip¹,Chang Elaine¹,Kwan Rainbow¹,Lin Sophia¹,Nelkenbrecher Karen¹,Sellers Benjamin D.²^ORCID,DiPasquale Antonio G.²,Chang Jae²,Pang Jodie²,Sojo Luis¹,Lindgren Andrea¹,Waldbrook Matthew¹,Xie Zhiwei¹,Young Clint¹,Johnson James P.¹,Robinette C. Lee¹,Cohen Charles J.¹,Safina Brian S.²^ORCID,Sutherlin Daniel P.²,Ortwine Daniel F.²,Dehnhardt Christoph M.¹^ORCID

Affiliation:

1. Xenon Pharmaceuticals Inc., 200-3650 Gilmore Way, Burnaby, British Columbia V5G 4W8, Canada

2. Genentech Inc., 1 DNA Way, South San Francisco, California 94080-4990, United States

3. ChemPartner, Building No. 5, 998 Halei Road, Zhangjiang Hi-Tech Park, Pudong New Area, Shanghai 201203, P. R. China

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.8b01621

Reference84 articles.

1. Systemic toxicity and cardiotoxicity from local anesthetics: Incidence and preventive measures