Development of a Novel Human Parathyroid Hormone Receptor 1 (hPTHR1) Agonist (CH5447240), a Potent and Orally Available Small Molecule for Treatment of Hypoparathyroidism
Author:
Affiliation:
1. Research Division, Chugai Pharmaceutical Co., Ltd., Komakado 1-135, Gotemba, Shizuoka 412-8513, Japan
Publisher
American Chemical Society (ACS)
Subject
Drug Discovery,Molecular Medicine
Link
https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.8b00182
Reference23 articles.
1. Progress, Paradox, and Potential: Parathyroid Hormone Research over Five Decades
2. Interactions of PTH and PTHrP with the PTH/PTHrP Receptor and with Downstream Signaling Pathways: Exceptions That Provide the Rules
3. Hypoparathyroidism
4. Hypoparathyroidism in the adult: Epidemiology, diagnosis, pathophysiology, target-organ involvement, treatment, and challenges for future research
5. Presentation of Hypoparathyroidism: Etiologies and Clinical Features
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