Cell-Active Small Molecule Inhibitors of the DNA-Damage Repair Enzyme Poly(ADP-ribose) Glycohydrolase (PARG): Discovery and Optimization of Orally Bioavailable Quinazolinedione Sulfonamides-Reference-Cited by-同舟云学术

Cell-Active Small Molecule Inhibitors of the DNA-Damage Repair Enzyme Poly(ADP-ribose) Glycohydrolase (PARG): Discovery and Optimization of Orally Bioavailable Quinazolinedione Sulfonamides

Published:2018-11-07 Issue:23 Volume:61 Page:10767-10792
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Waszkowycz Bohdan¹^ORCID,Smith Kate M.¹^ORCID,McGonagle Alison E.¹,Jordan Allan M.¹^ORCID,Acton Ben¹,Fairweather Emma E.¹,Griffiths Louise A.¹,Hamilton Niall M.¹,Hamilton Nicola S.¹,Hitchin James R.¹,Hutton Colin P.¹,James Dominic I.¹,Jones Clifford D.²,Jones Stuart¹,Mould Daniel P.¹^ORCID,Small Helen F.¹,Stowell Alexandra I. J.¹,Tucker Julie A.³,Waddell Ian D.¹,Ogilvie Donald J.¹

Affiliation:

1. Cancer Research UK Manchester Institute, The University of Manchester, Alderley Park, Maccelsfield SK10 4TG, U.K.

2. Oncology Innovative Medicines Unit, AstraZeneca, Alderley Park, Macclesfield Cheshire SK10 4TG, U.K.

3. Structure and Biophysics, Discovery Sciences, AstraZeneca, Alderley Park, Macclesfield, Cheshire SK10 4TG, U.K.

Funder

Cancer Research UK

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.8b01407

Reference39 articles.

1. The DNA damage response and cancer therapy

2. Targeting DNA damage response in cancer therapy

3. Targeting the DNA Damage Response in Cancer

4. PARG is recruited to DNA damage sites through poly(ADP-ribose)- and PCNA-dependent mechanisms

5. The recognition and removal of cellular poly(ADP-ribose) signals

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