Development of an N-Acyl Amino Acid That Selectively Inhibits the Glycine Transporter 2 To Produce Analgesia in a Rat Model of Chronic Pain-Reference-Cited by-同舟云学术

Development of an N-Acyl Amino Acid That Selectively Inhibits the Glycine Transporter 2 To Produce Analgesia in a Rat Model of Chronic Pain

Published:2019-02-04 Issue:5 Volume:62 Page:2466-2484
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Mostyn Shannon N.¹,Rawling Tristan²^ORCID,Mohammadi Sarasa¹,Shimmon Susan²,Frangos Zachary J.¹,Sarker Subhodeep¹,Yousuf Arsalan¹,Vetter Irina³,Ryan Renae M.¹^ORCID,Christie Macdonald J.¹,Vandenberg Robert J.¹^ORCID

Affiliation:

1. Discipline of Pharmacology, School of Medical Sciences, University of Sydney, Sydney, NSW 2006, Australia

2. School of Mathematical and Physical Sciences, Faculty of Science, The University of Technology Sydney, Sydney, NSW 2007, Australia

3. Institute for Molecular Bioscience & School of Pharmacy, The University of Queensland, Brisbane, Qld 4072, Australia

Funder

University of Sydney

Austrian Science Fund

National Health and Medical Research Council

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.8b01775

Reference44 articles.

1. Neuropathic Pain: A Maladaptive Response of the Nervous System to Damage

2. Central Sensitization: A Generator of Pain Hypersensitivity by Central Neural Plasticity

3. Modulation of Glycine-Mediated Spinal Neurotransmission for the Treatment of Chronic Pain

4. Clinical Effectiveness and Cost-Effectiveness of Treatments for Patients With Chronic Pain

5. Opioids and the treatment of chronic pain: Controversies, current status, and future directions.

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