Coagulation Factor XIIIa Inhibitor Tridegin: On the Role of Disulfide Bonds for Folding, Stability, and Function

Author:

Bäuml Charlotte A.1,Schmitz Thomas1,Paul George Ajay Abisheck1,Sudarsanam Monica1,Hardes Kornelia2,Steinmetzer Torsten2ORCID,Holle Lori A.3,Wolberg Alisa S.3,Pötzsch Bernd4,Oldenburg Johannes4,Biswas Arijit4,Imhof Diana1ORCID

Affiliation:

1. Pharmaceutical Biochemistry and Bioanalytics, Pharmaceutical Institute, University of Bonn, An der Immenburg 4, 53121 Bonn, Germany

2. Institute of Pharmaceutical Chemistry, Philipps University of Marburg, Marbacher Weg 6, 35032 Marburg, Germany

3. Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, 819 Brinkhous-Bullitt Building, Chapel Hill, North Carolina 27599, United States

4. Institute of Experimental Hematology and Transfusion Medicine, University Hospital Bonn, Sigmund-Freud-Str. 25, 53127 Bonn, Germany

Funder

Deutsche Stiftung f?r Herzforschung

National Institutes of Health

Rheinische Friedrich-Wilhelms-Universit?t Bonn

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

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