Potent Antiglioblastoma Agents by Hybridizing the Onium-Alkyloxy-Stilbene Based Structures of an α7-nAChR, α9-nAChR Antagonist and of a Pro-Oxidant Mitocan-Reference-Cited by-同舟云学术

Potent Antiglioblastoma Agents by Hybridizing the Onium-Alkyloxy-Stilbene Based Structures of an α7-nAChR, α9-nAChR Antagonist and of a Pro-Oxidant Mitocan

Published:2018-11-07 Issue:23 Volume:61 Page:10531-10544
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Bavo Francesco¹,Pucci Susanna²³,Fasoli Francesca²,Lammi Carmen¹^ORCID,Moretti Milena²⁴,Mucchietto Vanessa²,Lattuada Donatella⁴,Viani Paola⁴,De Palma Clara⁵,Budriesi Roberta⁶^ORCID,Corradini Irene²,Dowell Cheryl⁷,McIntosh J. Michael⁷⁸⁹,Clementi Francesco²⁴,Bolchi Cristiano¹^ORCID,Gotti Cecilia²⁴,Pallavicini Marco¹^ORCID

Affiliation:

1. Dipartimento di Scienze Farmaceutiche, Università degli Studi di Milano, Via Mangiagalli 25, I-20133 Milano, Italy

2. Institute of Neuroscience, CNR, Via Vanvitelli 32, I-20129 Milano, Italy

3. Hunimed University, Via Rita Levi-Montalcini 4, 20090 Pieve Emanuele (MI), Italy

4. Department of Medical Biotechnology and Translational Medicine, Università degli Studi di Milano, Via Vanvitelli 32, I-20129 Milano, Italy

5. Unit of Clinical Pharmacology, University Hospital “Luigi Sacco”-ASST Fatebenefratelli Sacco, Via G. B. Grassi 74, I-20157 Milano, Italy

6. Dipartimento di Farmacia e Biotecnologie, Università degli Studi di Bologna, Via Belmeloro 6, I-40126 Bologna, Italy

7. Department of Biology, University of Utah, 257S.1400 East, Salt Lake City, Utah 84112, United States

8. George E. Wahlen Veterans Affairs Medical Center, 500 Foothill Drive, Salt Lake City, Utah 84148, United States

9. Department of Psychiatry, University of Utah, 501 Chipeta Way, Salt Lake City, Utah 84108, United States

Funder

Consiglio Nazionale delle Ricerche

Fondazione Antonio Carlo Monzino

National Institute of General Medical Sciences

Fondazione Vollaro

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.8b01052

Reference24 articles.

1. Classification of mitocans, anti-cancer drugs acting on mitochondria

2. Novel Mitochondria-Targeted Furocoumarin Derivatives as Possible Anti-Cancer Agents

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5. Mitochondrial Targeting of Vitamin E Succinate Enhances Its Pro-apoptotic and Anti-cancer Activity via Mitochondrial Complex II

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