Design of a True Bivalent Ligand with Picomolar Binding Affinity for a G Protein-Coupled Receptor Homodimer-Reference-Cited by-同舟云学术

Design of a True Bivalent Ligand with Picomolar Binding Affinity for a G Protein-Coupled Receptor Homodimer

Published:2018-09-26 Issue:20 Volume:61 Page:9335-9346
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Pulido Daniel¹²,Casadó-Anguera Verònica³⁴⁵,Pérez-Benito Laura⁶,Moreno Estefanía³⁴⁵,Cordomí Arnau⁶^ORCID,López Laura⁶,Cortés Antoni³⁴⁵,Ferré Sergi⁷^ORCID,Pardo Leonardo⁶,Casadó Vicent³⁴⁵,Royo Miriam¹²^ORCID

Affiliation:

1. Biomaterials and Nanomedicine, Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Barcelona Science Park, 08028 Barcelona, Spain

2. Combinatorial Chemistry Unit, Barcelona Science Park, 08028 Barcelona, Spain

3. Department of Biochemistry and Molecular Biomedicine, Faculty of Biology, University of Barcelona, 08028 Barcelona, Spain

4. Biomedical Research Networking Center in Neurodegenerative Diseases (CIBERNED), 08028 Barcelona, Spain

5. Institute of Biomedicine, University of Barcelona (IBUB), 08028 Barcelona, Spain

6. Laboratory of Computational Medicine, Biostatistics Unit, Faculty of Medicine, Universitat Autònoma de Barcelona, 08193 Bellaterra, Spain

7. Integrative Neurobiology Section, National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health, Baltimore, Maryland 21224, United States

Funder

Departament d'Innovaci?, Universitats i Empresa, Generalitat de Catalunya

Centro de Investigaci?n Biom?dica en Red en Bioingenier?a, Biomateriales y Nanomedicina

European Regional Development Fund

Secretar?a de Estado de Investigaci?n, Desarrollo e Innovaci?n

National Institute on Drug Abuse

Fundaci? la Marat? de TV3

Centro de Investigaci?n Biom?dica en Red Enfermedades Neurodegenerativas

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine