Design of N-Benzoxaborole Benzofuran GSK8175—Optimization of Human Pharmacokinetics Inspired by Metabolites of a Failed Clinical HCV Inhibitor-Reference-Cited by-同舟云学术

Design of N-Benzoxaborole Benzofuran GSK8175—Optimization of Human Pharmacokinetics Inspired by Metabolites of a Failed Clinical HCV Inhibitor

Published:2019-02-14 Issue:7 Volume:62 Page:3254-3267
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Chong Pek Y.¹,Shotwell J. Brad¹^ORCID,Miller John¹,Price Daniel J.²,Maynard Andy¹,Voitenleitner Christian¹,Mathis Amanda¹,Williams Shawn³,Pouliot Jeffrey J.³,Creech Katrina³,Wang Feng³,Fang Jing³,Zhang Huichang³,Tai Vincent W.-F.¹,Turner Elizabeth¹,Kahler Kirsten M.¹,Crosby Renae¹,Peat Andrew J.³^ORCID

Affiliation:

1. GlaxoSmithKline, 5 Moore Drive, Research Triangle Park, North Carolina 27709, United States

2. GlaxoSmithKline, 200 Cambridge Park Drive, Cambridge, Massachusetts 02140, United States

3. GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, United States

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

http://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.8b01719

Reference33 articles.

1. Isolation of a cDNA cLone Derived from a Blood-Borne Non-A, Non-B Viral Hepatitis Genome

2. The HCV Revolution Did Not Happen Overnight

3. Ledipasvir/Sofosbuvir: A Review of Its Use in Chronic Hepatitis C

4. Ombitasvir/paritaprevir/ritonavir plus dasabuvir combination in the treatment of chronic HCV infection

5. WHO Progress report on access to hepatitis C treatment: focus on overcoming barriers in low- and middle-income countries. 2018 (WHO/CDS/HIV/18.4) http://www.who.int/hepatitis/publications/hep-c-access-report-2018/en/ (accessed Oct 2018).

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