[99mTc][Tc(N)PNP43]-Labeled RGD Peptides As New Probes for a Selective Detection of αvβ3 Integrin: Synthesis, Structure–Activity and Pharmacokinetic Studies

Author:

Bolzati Cristina1ORCID,Salvarese Nicola1ORCID,Carpanese Debora2,Seraglia Roberta1,Meléndez-Alafort Laura2,Rosato Antonio23,Capasso Domenica4,Saviano Michele5ORCID,Del Gatto Annarita6,Comegna Daniela6,Zaccaro Laura6ORCID

Affiliation:

1. Institute of Condensed Matter Chemistry and Technologies for Energy ICMATE-CNR, Corso Stati Uniti, 4, 35127 Padova, Italy

2. Veneto Institute of Oncology IOV-IRCCS, Via Gattamelata, 64, 35128 Padova, Italy

3. Department of Surgery, Oncology and Gastroenterology, University of Padua, via Gattamelata, 64, 35138 Padova, Italy

4. Department of Pharmacy, University of Naples ‘‘Federico II’’, Naples, Italy

5. Institute of Cristallography IC−CNR, Via Amendola 122/O, 70126 Bari, Italy

6. Institute of Biostructures and Bioimaging IBB-CNR, Via Mezzocannone 16, 80134 Napoli, Italy

Funder

Ministero dell’Istruzione, dell’Università e della Ricerca

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

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