3,17β-Bis-sulfamoyloxy-2-methoxyestra-1,3,5(10)-triene and Nonsteroidal Sulfamate Derivatives Inhibit Carbonic Anhydrase IX: Structure–Activity Optimization for Isoform Selectivity-Reference-Cited by-同舟云学术

3,17β-Bis-sulfamoyloxy-2-methoxyestra-1,3,5(10)-triene and Nonsteroidal Sulfamate Derivatives Inhibit Carbonic Anhydrase IX: Structure–Activity Optimization for Isoform Selectivity

Published:2019-02-05 Issue:4 Volume:62 Page:2202-2212
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Andring Jacob T.¹^ORCID,Dohle Wolfgang²,Tu Chingkuang¹,Potter Barry V. L.²^ORCID,McKenna Robert¹

Affiliation:

1. College of Medicine, Department of Biochemistry and Molecular Biology, University of Florida, Gainesville, Florida 32610, United States

2. Medicinal Chemistry & Drug Discovery, Department of Pharmacology, University of Oxford, Mansfield Road, Oxford OX1 3QT, U.K.

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.8b01990

Reference52 articles.

1. Targeting the Metabolic Microenvironment of Tumors

2. Targeting oncogenic vulnerabilities in triple negative breast cancer: biological bases and ongoing clinical studies

3. Boone, C. D.; Pinard, M.; McKenna, R.; Silverman, D. Carbonic Anhydrase: Mechanism, Regulation, Links to Disease, and Industrial Applications; Springer: Dordrecht, 2014; pp 31–52.

4. Design of a Carbonic Anhydrase IX Active-Site Mimic To Screen Inhibitors for Possible Anticancer Properties

5. Transcriptional control of the tumor- and hypoxia-marker carbonic anhydrase 9: A one transcription factor (HIF-1) show?

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