6-Amino-3-methylpyrimidinones as Potent, Selective, and Orally Efficacious SHP2 Inhibitors-Reference-Cited by-同舟云学术

6-Amino-3-methylpyrimidinones as Potent, Selective, and Orally Efficacious SHP2 Inhibitors

Published:2019-01-28 Issue:4 Volume:62 Page:1793-1802
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Sarver Patrick,Acker Michael,Bagdanoff Jeffrey T.,Chen Zhouliang,Chen Ying-Nan,Chan Homan,Firestone Brant,Fodor Michelle,Fortanet Jorge,Hao Huaixiang,Hentemann Murphy,Kato Mitsunori,Koenig Robert,LaBonte Laura R.,Liu Gang,Liu Shumei,Liu Chen,McNeill Eric,Mohseni Morvarid,Sendzik Martin,Stams Travis,Spence Stan,Tamez Victoriano,Tichkule Ritesh,Towler Christopher,Wang Hongyun,Wang Ping,Williams Sarah L.,Yu Bing,LaMarche Matthew J.^ORCID

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

http://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.8b01726

Reference45 articles.

1. Mutations in PTPN11, encoding the protein tyrosine phosphatase SHP-2, cause Noonan syndrome

2. Somatic mutations in PTPN11 in juvenile myelomonocytic leukemia, myelodysplastic syndromes and acute myeloid leukemia

3. Myeloid Dysregulation in a Human Induced Pluripotent Stem Cell Model of PTPN11 -Associated Juvenile Myelomonocytic Leukemia

4. Activating Mutations of the Noonan Syndrome-Associated SHP2/PTPN11 Gene in Human Solid Tumors and Adult Acute Myelogenous Leukemia

5. The tyrosine phosphatase Shp2 (PTPN11) in cancer

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