Optimization of N-Substituted Oseltamivir Derivatives as Potent Inhibitors of Group-1 and -2 Influenza A Neuraminidases, Including a Drug-Resistant Variant-Reference-Cited by-同舟云学术

Optimization of N-Substituted Oseltamivir Derivatives as Potent Inhibitors of Group-1 and -2 Influenza A Neuraminidases, Including a Drug-Resistant Variant

Published:2018-07-02 Issue:14 Volume:61 Page:6379-6397
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Zhang Jian¹^ORCID,Poongavanam Vasanthanathan²^ORCID,Kang Dongwei¹^ORCID,Bertagnin Chiara³,Lu Huamei⁴,Kong Xiujie¹,Ju Han¹,Lu Xueyi¹,Gao Ping¹,Tian Ye¹,Jia Haiyong¹,Desta Samuel¹,Ding Xiao¹,Sun Lin¹,Fang Zengjun⁵,Huang Boshi¹^ORCID,Liang Xuewu¹,Jia Ruifang¹,Ma Xiuli⁴,Xu Wenfang¹,Murugan Natarajan Arul⁶,Loregian Arianna³,Huang Bing⁴,Zhan Peng¹,Liu Xinyong¹

Affiliation:

1. Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, 44 West Culture Road, 250012 Jinan, Shandong, P.R. China

2. Department of Physics, Chemistry, and Pharmacy, University of Southern Denmark, DK-5230 Odense M., Denmark

3. Department of Molecular Medicine, University of Padova, via Gabelli 63, 35121 Padova, Italy

4. Institute of Poultry Science, Shandong Academy of Agricultural Sciences, 1, Jiaoxiao Road, Jinan, Shandong 250023, P. R. China

5. The Second Hospital of Shandong University, no. 247 Beiyuan Avenue, Jinan 250033, China

6. Division of Theoretical Chemistry and Biology, School of Biotechnology, KTH Royal Institute of Technology, S-106 91 Stockholm, Sweden

Funder

Shandong Province

Associazione Italiana per la Ricerca sul Cancro

Shandong University

National Natural Science Foundation of China

Università degli Studi di Padova

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.8b00929

Reference72 articles.

1. Influenza A Virus N5 Neuraminidase Has an Extended 150-Cavity

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3. Antiviral Potential and Molecular Insight into Neuraminidase Inhibiting Diarylheptanoids from Alpinia katsumadai

4. Influenza Fact Sheet 211; World Health Organization: Geneva, 2018; http://www.who.int/mediacentre/factsheets/fs211/en/ (accessed January 31, 2018).

5. Global Epidemiology of Influenza: Past and Present

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