New Generation of Selective Androgen Receptor Degraders: Our Initial Design, Synthesis, and Biological Evaluation of New Compounds with Enzalutamide-Resistant Prostate Cancer Activity-Reference-Cited by-同舟云学术

New Generation of Selective Androgen Receptor Degraders: Our Initial Design, Synthesis, and Biological Evaluation of New Compounds with Enzalutamide-Resistant Prostate Cancer Activity

Published:2018-12-07 Issue:2 Volume:62 Page:491-511
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Hwang Dong-Jin¹,He Yali¹,Ponnusamy Suriyan²,Mohler Michael L.¹³^ORCID,Thiyagarajan Thirumagal²,McEwan Iain J.⁴,Narayanan Ramesh²,Miller Duane D.¹^ORCID

Affiliation:

1. Department of Pharmaceutical Sciences, University of Tennessee Health Science Center, Memphis, Tennessee 38163, United States

2. Department of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee 38163, United States

3. GTx, Inc., Memphis, Tennessee 38103, United States

4. School of Medicine, Medical Sciences and Nutrition, Institute of Medical Sciences, University of Aberdeen, Aberdeen AB25 2ZD, Scotland, U.K.

Funder

University of Tennessee Health Science Center

GTx, Inc.

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.8b00973

Reference60 articles.

1. Discovery of 1H-Indole-2-carboxamides as Novel Inhibitors of the Androgen Receptor Binding Function 3 (BF3)

2. Androgen Receptor: Past, Present and Future

3. Cancer statistics, 2018

4. Global cancer statistics, 2012

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