Discovery of Novel Pyrazole-Based Selective Aldosterone Synthase (CYP11B2) Inhibitors: A New Template to Coordinate the Heme-Iron Motif of CYP11B2-Reference-Cited by-同舟云学术

Discovery of Novel Pyrazole-Based Selective Aldosterone Synthase (CYP11B2) Inhibitors: A New Template to Coordinate the Heme-Iron Motif of CYP11B2

Published:2018-06-07 Issue:13 Volume:61 Page:5594-5608
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Sakakibara Ryo¹^ORCID,Sasaki Wataru¹,Onda Yuichi¹,Yamaguchi Minami¹,Ushirogochi Hideki¹,Hiraga Yuki¹,Sato Kanako¹,Nishio Masashi¹,Egi Yasuhiro¹,Takedomi Kei¹,Shimizu Hidetoshi¹,Ohbora Tomoko¹,Akahoshi Fumihiko¹

Affiliation:

1. Sohyaku, Innovative Research Division, Mitsubishi Tanabe Pharma Corporation, 2-2-50, Kawagishi, Toda, Saitama 335-8505, Japan

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.8b00328

Reference50 articles.

1. Serum Aldosterone and the Incidence of Hypertension in Nonhypertensive Persons

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3. Aldosterone and the Risk of Hypertension

4. Vascular Actions of Aldosterone

5. Evidence for an increased rate of cardiovascular events in patients with primary aldosteronism

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