Optimization of 1,4-Oxazine β-Secretase 1 (BACE1) Inhibitors Toward a Clinical Candidate-Reference-Cited by-同舟云学术

Optimization of 1,4-Oxazine β-Secretase 1 (BACE1) Inhibitors Toward a Clinical Candidate

Published:2018-05-29 Issue:12 Volume:61 Page:5292-5303
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Gijsen Harrie J. M.¹^ORCID,Alonso de Diego Sergio A.²,De Cleyn Michel¹,García-Molina Aránzazu²,Macdonald Gregor J.¹,Martínez-Lamenca Carolina¹,Oehlrich Daniel¹^ORCID,Prokopcova Hana¹,Rombouts Frederik J. R.¹^ORCID,Surkyn Michel¹,Trabanco Andrés A.²^ORCID,Van Brandt Sven¹,Van den Bossche Dries¹,Van Gool Michiel²,Austin Nigel³,Borghys Herman³,Dhuyvetter Deborah³,Moechars Diederik⁴

Affiliation:

1. Neuroscience Medicinal Chemistry, Janssen Research & Development, Janssen Pharmaceutica NV, Turnhoutseweg 30, B-2340 Beerse, Belgium

2. Neuroscience Medicinal Chemistry, Janssen Research & Development, Janssen−Cilag SA, C/Jarama 75A, 45007 Toledo, Spain

3. Discovery Sciences, Janssen Research & Development, Janssen Pharmaceutica NV, Turnhoutseweg 30, B-2340 Beerse, Belgium

4. Neuroscience Biology, Janssen Research & Development, Janssen Pharmaceutica NV, Turnhoutseweg 30, B-2340 Beerse, Belgium

Funder

Agentschap Innoveren en Ondernemen

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.8b00304

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