Structure Guided Lead Generation toward Nonchiral M. tuberculosis Thymidylate Kinase Inhibitors-Reference-Cited by-同舟云学术

Structure Guided Lead Generation toward Nonchiral M. tuberculosis Thymidylate Kinase Inhibitors

Published:2018-03-06 Issue:7 Volume:61 Page:2753-2775
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Song Lijun¹,Merceron Romain²³,Gracia Begoña⁴⁵,Quintana Ainhoa Lucía⁴⁵,Risseeuw Martijn D. P.¹,Hulpia Fabian¹,Cos Paul⁶,Aínsa José A.⁴⁵,Munier-Lehmann Hélène⁷,Savvides Savvas N.²³,Van Calenbergh Serge¹^ORCID

Affiliation:

1. Laboratory for Medicinal Chemistry (FFW), Ghent University, Ottergemsesteenweg 460, B-9000 Gent, Belgium

2. VIB Center for Inflammation Research, Zwijnaarde, Ghent 9052, Belgium

3. Department of Biochemistry and Microbiology, Ghent University, Ghent 9000, Belgium

4. Grupo de Genética de Micobacterias, Departamento de Microbiología, Facultad de Medicina, and BIFI, Universidad de Zaragoza, Zaragoza, Spain

5. CIBER Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III, 28029 Madrid, Spain

6. Laboratory for Microbiology, Parasitology and Hygiene (LMPH), Department of Pharmaceutical Sciences, University of Antwerp, Campus Drie Eiken, Universiteitsplein 1, B-2610 Antwerpen, Belgium

7. Unit of Chemistry and Biocatalysis, Department of Structural Biology and Chemistry, Institut Pasteur, CNRS UMR3523, 28 Rue du Dr. Roux, Cedex 15 75724 Paris, France

Funder

Vlaams Instituut voor Biotechnologie

Fonds Wetenschappelijk Onderzoek

China Scholarship Council

Herculesstichting, Vlaamse Overheid

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.7b01570

Reference56 articles.

1. WHO. Global Tuberculosis Report 2017; World Health Organization: Geneva, 2017. http://www.who.int/tb/publications/global_report/en/ (accessed March 5, 2018).

2. Myths and misconceptions: the origin and evolution of Mycobacterium tuberculosis

3. Mycobacterium tuberculosis Pathogenesis and Molecular Determinants of Virulence

4. Tuberculosis

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