Small-Molecule Inhibitors of the Programmed Cell Death-1/Programmed Death-Ligand 1 (PD-1/PD-L1) Interaction via Transiently Induced Protein States and Dimerization of PD-L1

Author:

Guzik Katarzyna1,Zak Krzysztof M.23,Grudnik Przemyslaw23,Magiera Katarzyna13,Musielak Bogdan1,Törner Ricarda1,Skalniak Lukasz1ORCID,Dömling Alexander4ORCID,Dubin Grzegorz23,Holak Tad A.13ORCID

Affiliation:

1. Department of Organic Chemistry, Faculty of Chemistry, Jagiellonian University, Ingardena 3, 30-060 Krakow, Poland

2. Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Gronostajowa 7, 30-387 Krakow, Poland

3. Malopolska Centre of Biotechnology, Jagiellonian University, Gronostajowa 7a, 30-387 Krakow, Poland

4. Department for Drug Design, University of Groningen, A. Deusinglaan 9, AV 9713 Groningen, The Netherlands

Funder

FP7 People: Marie-Curie Actions

Narodowe Centrum Nauki

Krajowy Naukowy Osrodek Wiodacy

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

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