Identification and Optimization of Pyrrolo[3,2-d]pyrimidine Toll-like Receptor 7 (TLR7) Selective Agonists for the Treatment of Hepatitis B-Reference-Cited by-同舟云学术

Identification and Optimization of Pyrrolo[3,2-d]pyrimidine Toll-like Receptor 7 (TLR7) Selective Agonists for the Treatment of Hepatitis B

Published:2017-07-14 Issue:14 Volume:60 Page:6137-6151
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

McGowan David C.¹^ORCID,Herschke Florence¹,Pauwels Frederik¹,Stoops Bart¹,Smyej Ilham¹,Last Stefaan¹,Pieters Serge¹,Embrechts Werner¹,Khamlichi Mourad Daoubi²,Thoné Tine¹,Van Schoubroeck Bertrand¹,Mostmans Wendy¹,Wuyts Debbie¹,Verstappen Dorien¹,Scholliers Annick¹,De Pooter Dorien¹,Dhuyvetter Deborah¹,Borghys Herman¹,Tuefferd Marianne¹,Arnoult Eric³,Hong Jin⁴,Fanning Gregory¹,Bollekens Jacques¹,Urmaliya Vijay¹,Teisman Ard¹,Horton Helen¹,Jonckers Tim H. M.¹,Raboisson Pierre¹

Affiliation:

1. Janssen Pharmaceutica, N. V. Turnhoutseweg 30, 2340 Beerse, Belgium

2. Villapharma Research S.L., Parque Tecnológico de Fuente Álamo, Ctra. El Estrecho-Lobosillo, Km. 2.5-Av. Azul, 30320 Fuente Álamo de Murcia, Murcia, Spain

3. Janssen Research & Development L.L.C., 1400 McKean Road, Spring House, Pennsylvania 19454, United States

4. Alios Biopharma, Inc., 260 East Grand Avenue, South San Francisco, California 94080, United States

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.7b00365

Reference44 articles.

1. Hepatitis B Virus Infection

2. A Comparison of Entecavir and Lamivudine for HBeAg-Positive Chronic Hepatitis B

3. Benefits and risks of interferon therapy for hepatitis B

4. AASLD guidelines for treatment of chronic hepatitis B

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