A Systematic Exploration of Macrocyclization in Apelin-13: Impact on Binding, Signaling, Stability, and Cardiovascular Effects-Reference-Cited by-同舟云学术

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A Systematic Exploration of Macrocyclization in Apelin-13: Impact on Binding, Signaling, Stability, and Cardiovascular Effects

Published:2018-02-20 Issue:6 Volume:61 Page:2266-2277
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Trân Kien¹²,Murza Alexandre¹²,Sainsily Xavier¹²,Coquerel David³²,Côté Jérôme¹²,Belleville Karine¹²,Haroune Lounès¹²^ORCID,Longpré Jean-Michel¹²,Dumaine Robert¹²,Salvail Dany⁴,Lesur Olivier³²,Auger-Messier Mannix³,Sarret Philippe¹²,Marsault Éric¹²^ORCID

Affiliation:

1. Département de Pharmacologie-Physiologie, Faculté de Médecine et des Sciences de la Santé, Université de Sherbrooke, Sherbrooke J1H 5N4, Québec, Canada

2. Institut de Pharmacologie de Sherbrooke, Sherbrooke J1H 5N4, Québec Canada

3. Département de Médecine, Faculté de Médecine et des Sciences de la Santé, Université de Sherbrooke, Sherbrooke J1H 5N4, Québec, Canada

4. IPS Thérapeutique Inc., Sherbrooke J1G 5J6, Québec, Canada

Funder

Fonds de Recherche du Qu?bec - Sant?

Canadian Institutes of Health Research

Government of Canada

Merck Sharp and Dohme

Canada Foundation for Innovation

Canada Research Chairs

Universit? de Sherbrooke

Natural Sciences and Engineering Research Council of Canada

Heart and Stroke Foundation of Canada

Mitacs

Programme Canadien de Bourses de la Francophonie

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.7b01353

Reference64 articles.

1. A human gene that shows identity with the gene encoding the angiotensin receptor is located on chromosome 11

2. Isolation and Characterization of a Novel Endogenous Peptide Ligand for the Human APJ Receptor

3. Characterization of the 5'‐regulatory regions of the rat and human apelin genes and regulation of breast apelin by USF

4. Preferential apelin-13 production by the proprotein convertase PCSK3 is implicated in obesity

5. [Pyr1]Apelin-13(1–12) Is a Biologically Active ACE2 Metabolite of the Endogenous Cardiovascular Peptide [Pyr1]Apelin-13

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1. Apelin stimulation of the vascular skeletal muscle stem cell niche enhances endogenous repair in dystrophic mice;Science Translational Medicine;2024-03-20

2. Insights on Structure–Passive Permeability Relationship in Pyrrole and Furan-Containing Macrocycles;Journal of Medicinal Chemistry;2024-02-28

3. Apelin is a peptide increasing tolerance of organs and cells to ischemia and reperfusion. The molecular mechanism (the review);The Siberian Journal of Clinical and Experimental Medicine;2024-01-11

4. Structure-Based Design and Synthesis of Stapled ¹⁰Panx1 Analogues for Use in Cardiovascular Inflammatory Diseases;Journal of Medicinal Chemistry;2023-09-13

5. Apelin prevents diabetes-induced poor collateral vessel formation and blood flow reperfusion in ischemic limb;Frontiers in Cardiovascular Medicine;2023-08-11

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