Identification of a Potent, Highly Selective, and Brain Penetrant Phosphodiesterase 2A Inhibitor Clinical Candidate-Reference-Cited by-同舟云学术

Identification of a Potent, Highly Selective, and Brain Penetrant Phosphodiesterase 2A Inhibitor Clinical Candidate

Published:2018-01-16 Issue:3 Volume:61 Page:1001-1018
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Helal Christopher J.¹^ORCID,Arnold Eric¹,Boyden Tracey¹,Chang Cheng¹,Chappie Thomas A.²,Fisher Ethan¹,Hajos Mihaly¹,Harms John F.²,Hoffman William E.¹,Humphrey John M.¹^ORCID,Pandit Jayvardhan¹,Kang Zhijun¹,Kleiman Robin J.¹,Kormos Bethany L.²,Lee Che-Wah¹,Lu Jiemin¹,Maklad Noha¹,McDowell Laura¹,McGinnis Dina¹,O’Connor Rebecca E.¹,O’Donnell Christopher J.¹^ORCID,Ogden Adam¹,Piotrowski Mary¹,Schmidt Christopher J.²,Seymour Patricia A.¹,Ueno Hirokazu¹,Vansell Nichole¹,Verhoest Patrick R.²,Yang Edward X.¹

Affiliation:

1. Pfizer Worldwide Research and Development, Eastern Point Road, Groton, Connecticut 06340, United States

2. Pfizer Worldwide Research and Development, 1 Portland Street, Cambridge, Massachusetts 02139, United States

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.7b01466

Reference24 articles.

1. Immunohistochemical Localization of Phosphodiesterase 2A in Multiple Mammalian Species

2. Inhibition of phosphodiesterase 2 increases neuronal cGMP, synaptic plasticity and memory performance