Conformational Propensity and Biological Studies of Proline Mutated LR Peptides Inhibiting Human Thymidylate Synthase and Ovarian Cancer Cell Growth-Reference-Cited by-同舟云学术

Conformational Propensity and Biological Studies of Proline Mutated LR Peptides Inhibiting Human Thymidylate Synthase and Ovarian Cancer Cell Growth

Published:2018-07-23 Issue:16 Volume:61 Page:7374-7380
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Saxena Puneet¹,Severi Leda¹,Santucci Matteo¹,Taddia Laura¹,Ferrari Stefania¹^ORCID,Luciani Rosaria¹,Marverti Gaetano²,Marraccini Chiara¹,Tondi Donatella¹^ORCID,Mor Marco³^ORCID,Scalvini Laura³^ORCID,Vitiello Simone¹,Losi Lorena¹⁴,Fonda Sergio¹,Pacifico Salvatore⁵,Guerrini Remo⁵⁶,D’Arca Domenico²,Ponterini Glauco¹,Costi Maria Paola¹^ORCID

Affiliation:

1. Department of Life Sciences, University of Modena and Reggio Emilia, Via Campi 103, 41125 Modena, Italy

2. Department of Biomedical Sciences, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Via Campi 287, 41125 Modena, Italy

3. Dipartimento di Scienze degli Alimenti e del Farmaco, Università di Parma, Parco Area delle Scienze 27/A, I-43124 Parma, Italy

4. Pathological Anatomy, Via del Pozzo 71, 41124 Modena, Italy

5. Department of Chemical and Pharmaceutical Sciences, University of Ferrara, Via Luigi Borsari 46, 44121 Ferrara, Italy

6. LTTA (Laboratorio per le Tecnologie delle Terapie Avanzate), Via Fossato di Mortara 17-19, 44100 Ferrara, Italy

Funder

Associazione Italiana per la Ricerca sul Cancro

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.7b01699

Reference37 articles.

1. The role of thymidylate synthase as an RNA binding protein

2. Autoregulation of human thymidylate synthase messenger RNA translation by thymidylate synthase.

3. Identification of an RNA binding site for human thymidylate synthase.

4. Thymidylate synthase as a translational regulator of cellular gene expression

5. THE CATALYTIC MECHANISM AND STRUCTURE OF THYMIDYLATE SYNTHASE

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