Expanding Benzoxazole-Based Inosine 5′-Monophosphate Dehydrogenase (IMPDH) Inhibitor Structure–Activity As Potential Antituberculosis Agents

Author:

Chacko Shibin,Boshoff Helena I. M.1ORCID,Singh Vinayak2,Ferraris Davide M.3,Gollapalli Deviprasad R.,Zhang Minjia,Lawson Ann P.,Pepi Michael J.,Joachimiak Andrzej45,Rizzi Menico3,Mizrahi Valerie6ORCID,Cuny Gregory D.7,Hedstrom LizbethORCID

Affiliation:

1. Tuberculosis Research Section, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892, United States

2. Department of Drug Discovery and Development & Institute of Infectious Disease and Molecular Medicine, H3D Drug Discovery and Development Centre, University of Cape Town, Rondebosch, Cape Town 7701, South Africa

3. Dipartimento di Scienze del Farmaco, Universitá del Piemonte Orientale, Via Bovio 6, 28100 Novara, Italy

4. Center for Structural Genomics of Infectious Diseases and Department of Biochemistry and Molecular Biology, University of Chicago, Chicago, Illinois 60557, United States

5. Structural Biology Center, Biosciences, Argonne National Laboratory, 9700 S. Cass Avenue, Argonne, Illinois 60439, United States

6. MRC/NHLS/UCT Molecular Mycobacteriology Research Unit & DST/NRF Centre of Excellence for Biomedical TB Research, Institute of Infectious Disease and Molecular Medicine & Department of Pathology, University of Cape Town, Anzio Road, Observatory 7925, South Africa

7. Department of Pharmacological and Pharmaceutical Sciences, College of Pharmacy, University of Houston, Health Building 2, 4849 Calhoun Road, Houston, Texas 77204, United States

Funder

Division of Intramural Research, National Institute of Allergy and Infectious Diseases

National Institute of Allergy and Infectious Diseases

National Research Foundation

South African Medical Research Council

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

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