Fragment-Based Drug Discovery of Inhibitors of Phosphopantetheine Adenylyltransferase from Gram-Negative Bacteria

Author:

Moreau Robert J.1ORCID,Skepper Colin K.1,Appleton Brent A.1,Blechschmidt Anke1,Balibar Carl J.1,Benton Bret M.1,Drumm Joseph E.1,Feng Brian Y.1ORCID,Geng Mei1,Li Cindy1,Lindvall Mika K.1,Lingel Andreas1ORCID,Lu Yipin1,Mamo Mulugeta1,Mergo Wosenu1,Polyakov Valery1,Smith Thomas M.1,Takeoka Kenneth1,Uehara Kyoko1,Wang Lisha1,Wei Jun-Rong1,Weiss Andrew H.1,Xie Lili1,Xu Wenjian1,Zhang Qiong1,de Vicente Javier1

Affiliation:

1. Novartis Institutes for BioMedical Research, 5300 Chiron Way, Emeryville, California 94608, United States

Funder

Novartis

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Reference86 articles.

1. Resistance to Antibiotics: Are We in the Post-Antibiotic Era?

2. World Health Organization. Antimicrobial Resistance: Global Report on Surveillance; 2014.

3. Centers for Disease Control and Prevention. Antibiotic resistance threats in the United States, 2013. https://www.cdc.gov/drugresistance/pdf/ar-threats-2013-508.pdf (accessed Nov 15, 2017).

4. Prevention of Drug Access to Bacterial Targets: Permeability Barriers and Active Efflux

5. The bacterial outer membrane as a drug barrier

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