Discovery and Optimization of Potent, Cell-Active Pyrazole-Based Inhibitors of Lactate Dehydrogenase (LDH)-Reference-Cited by-同舟云学术

Discovery and Optimization of Potent, Cell-Active Pyrazole-Based Inhibitors of Lactate Dehydrogenase (LDH)

Published:2017-11-09 Issue:22 Volume:60 Page:9184-9204
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Rai Ganesha¹,Brimacombe Kyle R.¹,Mott Bryan T.¹,Urban Daniel J.¹,Hu Xin¹,Yang Shyh-Ming¹,Lee Tobie D.¹,Cheff Dorian M.¹,Kouznetsova Jennifer¹,Benavides Gloria A.²,Pohida Katie¹,Kuenstner Eric J.¹,Luci Diane K.¹,Lukacs Christine M.³,Davies Douglas R.³,Dranow David M.³,Zhu Hu¹,Sulikowski Gary⁴,Moore William J.⁵,Stott Gordon M.⁵,Flint Andrew J.⁵,Hall Matthew D.¹^ORCID,Darley-Usmar Victor M.²,Neckers Leonard M.⁶,Dang Chi V.⁷,Waterson Alex G.⁴,Simeonov Anton¹,Jadhav Ajit¹,Maloney David J.¹^ORCID

Affiliation:

1. National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville, Maryland 20850, United States

2. Mitochondrial Medicine Laboratory, Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama 35294, United States

3. Beryllium Discovery Corp., 7869 Day Road West, Bainbridge Island, Washington 98110, United States

4. Vanderbilt Institute of Chemical Biology, Vanderbilt University, Nashville, Tennessee 37232, United States

5. NExT Program Support, Applied/Developmental Research Directorate, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland 21702, United States

6. Urologic Oncology Branch, Center for Cancer Research, National Cancer Institute, 9000 Rockville Pike, Bethesda, Maryland 20892, United States

7. Abramson Cancer Center, Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadephia, Pennsylvania 19104, United States

Funder

National Center for Advancing Translational Sciences

National Cancer Institute

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.7b00941

Reference49 articles.

1. Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

2. Overexpression of lactate dehydrogenase-A in human intrahepatic cholangiocarcinoma: its implication for treatment