Discovery of a Novel Piperidine-Based Inhibitor of Cholesteryl Ester Transfer Protein (CETP) That Retains Activity in Hypertriglyceridemic Plasma-Reference-Cited by-同舟云学术

Discovery of a Novel Piperidine-Based Inhibitor of Cholesteryl Ester Transfer Protein (CETP) That Retains Activity in Hypertriglyceridemic Plasma

Published:2017-10-16 Issue:20 Volume:60 Page:8466-8481
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Yamada Ken¹²^ORCID,Brousseau Margaret¹,Honma Wataru²,Iimura Akiko²,Imase Hidetomo¹²,Iwaki Yuki¹²,Kawanami Toshio¹²,LaSala Daniel³,Liang Guiqing¹,Mitani Hironobu²,Nonomura Kazuhiko²,Ohmori Osamu²,Pan Meihui¹,Rigel Dean F.³,Umemura Ichiro²,Yasoshima Kayo¹²,Zhu Guoming¹,Mogi Muneto¹²

Affiliation:

1. Novartis Institutes for BioMedical Research, Inc., 250 Massachusetts Avenue, Cambridge, Massachusetts 02139-4133, United States

2. Novartis Institutes for BioMedical Research, Novartis Pharma K.K., Ohkubo 8, Tsukuba, Ibaraki 300-2611, Japan

3. Novartis Institutes for BioMedical Research, Novartis Pharmaceuticals Corporation, 1 Health Plaza, East Hanover, New Jersey 07936-1080, United States

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.7b00900

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1. Interpretation of the evidence for the efficacy and safety of statin therapy

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4. Cholesteryl Ester Transfer Protein

5. Association of Cholesteryl Ester Transfer Protein Genotypes With CETP Mass and Activity, Lipid Levels, and Coronary Risk

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