Design of Novel 3-Pyrimidinylazaindole CDK2/9 Inhibitors with Potent In Vitro and In Vivo Antitumor Efficacy in a Triple-Negative Breast Cancer Model-Reference-Cited by-同舟云学术

Design of Novel 3-Pyrimidinylazaindole CDK2/9 Inhibitors with Potent In Vitro and In Vivo Antitumor Efficacy in a Triple-Negative Breast Cancer Model

Published:2017-12-05 Issue:23 Volume:60 Page:9470-9489
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Singh Umed¹,Chashoo Gousia²,Khan Sameer U.²,Mahajan Priya³,Nargotra Amit³^ORCID,Mahajan Girish²,Singh Amarinder⁴,Sharma Anjna⁴,Mintoo Mubashir J.²,Guru Santosh Kumar²,Aruri Hariprasad¹,Thatikonda Thanusha¹,Sahu Promod⁴,Chibber Pankaj⁴,Kumar Vikas⁵,Mir Sameer A.²,Bharate Sonali S.⁵,Madishetti Sreedhar⁴,Nandi Utpal⁴,Singh Gurdarshan⁴,Mondhe Dilip Manikrao²,Bhushan Shashi²⁶,Malik Fayaz²,Mignani Serge¹⁷,Vishwakarma Ram A.¹^ORCID,Singh Parvinder Pal¹^ORCID

Affiliation:

1. Medicinal Chemistry Division, CSIR-Indian Institute of Integrative Medicine, Academy of Scientific and Innovative Research, Canal Road, Jammu, Jammu & Kashmir-180001, India

2. Cancer Pharmacology Division, CSIR-Indian Institute of Integrative Medicine, Academy of Scientific and Innovative Research, Canal Road, Jammu, Jammu & Kashmir-180001, India

3. Discovery Informatics, CSIR-Indian Institute of Integrative Medicine, Academy of Scientific and Innovative Research, Canal Road, Jammu, Jammu & Kashmir-180001, India

4. Pharmacokinetic & Pharmacodynamic Division, CSIR-Indian Institute of Integrative Medicine, Academy of Scientific and Innovative Research, Canal Road, Jammu, Jammu & Kashmir-180001, India

5. Preformulation Division, CSIR-Indian Institute of Integrative Medicine, Academy of Scientific and Innovative Research, Canal Road, Jammu, Jammu & Kashmir-180001, India

6. Indian Pharmacopoeia Commission, Sector-23, Raj Nagar, Ghaziabad-201002, India

7. PRES Sorbonne Paris Cité, CNRS UMR 860, Laboratoire de Chimie et de Biochimie Pharmacologiques et Toxicologique, Université Paris Descartes, 45, rue des Saints Péres, 75006 Paris, France

Funder

Council of Scientific and Industrial Research

University Grants Commission

Department of Science and Technology, Ministry of Science and Technology

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.7b00663

Reference51 articles.

1. Cell cycle kinases as therapeutic targets for cancer