Discovery of a Novel and Selective Indoleamine 2,3-Dioxygenase (IDO-1) Inhibitor 3-(5-Fluoro-1H-indol-3-yl)pyrrolidine-2,5-dione (EOS200271/PF-06840003) and Its Characterization as a Potential Clinical Candidate-Reference-Cited by-同舟云学术

Discovery of a Novel and Selective Indoleamine 2,3-Dioxygenase (IDO-1) Inhibitor 3-(5-Fluoro-1H-indol-3-yl)pyrrolidine-2,5-dione (EOS200271/PF-06840003) and Its Characterization as a Potential Clinical Candidate

Published:2017-11-21 Issue:23 Volume:60 Page:9617-9629
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Crosignani Stefano¹,Bingham Patrick²,Bottemanne Pauline¹,Cannelle Hélène¹,Cauwenberghs Sandra¹,Cordonnier Marie¹,Dalvie Deepak²,Deroose Frederik³,Feng Jun Li²,Gomes Bruno¹,Greasley Samantha²,Kaiser Stephen E²,Kraus Manfred²,Négrerie Michel⁴,Maegley Karen²,Miller Nichol²,Murray Brion W²,Schneider Manfred¹,Soloweij James²,Stewart Albert E²,Tumang Joseph²,Torti Vince R²,Van Den Eynde Benoit⁵,Wythes Martin²

Affiliation:

1. iTeos Therapeutics, Rue des Frères Wright 29, 6041 Gosselies, Belgium

2. La Jolla Laboratories, Pfizer Global Research and Development, 10770 Science Center Drive, San Diego, California 92121, United States

3. Asclepia Outsourcing Solutions, Damvalleistraat 49, Destelbergen 9070, Belgium

4. Ecole Polytechnique, Unité Inserm 1182 UMR 7645, Route de Saclay, Palaiseau 91128, France

5. Ludwig Institute for Cancer Research, Université Catholique de Louvain, 74 Avenue Hippocrate, 1200 Brussels, Belgium

Funder

European Regional Development Fund

Région Wallonne

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.7b00974

Reference26 articles.

1. Combination cancer immunotherapy and new immunomodulatory targets

2. Indoleamine 2,3 dioxygenase and metabolic control of immune responses

3. Tryptophan-Degrading Enzymes in Tumoral Immune Resistance

4. Evidence for a tumoral immune resistance mechanism based on tryptophan degradation by indoleamine 2,3-dioxygenase

5. Indoleamine 2,3-Dioxygenase Serves as a Marker of Poor Prognosis in Gene Expression Profiles of Serous Ovarian Cancer Cells

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