7-Substituted 2-Nitro-5,6-dihydroimidazo[2,1-b][1,3]oxazines: Novel Antitubercular Agents Lead to a New Preclinical Candidate for Visceral Leishmaniasis

Author:

Thompson Andrew M.1ORCID,O’Connor Patrick D.1,Marshall Andrew J.1,Yardley Vanessa2,Maes Louis3,Gupta Suman4,Launay Delphine5,Braillard Stephanie5,Chatelain Eric5,Franzblau Scott G.6,Wan Baojie6,Wang Yuehong6,Ma Zhenkun7,Cooper Christopher B.7,Denny William A.1

Affiliation:

1. Auckland Cancer Society Research Centre, School of Medical Sciences, The University of Auckland, Private Bag 92019, Auckland 1142, New Zealand

2. Faculty of Infectious & Tropical Diseases, London School of Hygiene & Tropical Medicine, Keppel Street, London WC1E 7HT, United Kingdom

3. Laboratory for Microbiology, Parasitology and Hygiene, Faculty of Pharmaceutical, Biomedical and Veterinary Sciences, University of Antwerp, Universiteitsplein 1, B-2610 Antwerp, Belgium

4. Division of Parasitology, CSIR—Central Drug Research Institute, Lucknow 226031, India

5. Drugs for Neglected Diseases initiative, 15 Chemin Louis Dunant, 1202 Geneva, Switzerland

6. Institute for Tuberculosis Research, College of Pharmacy, University of Illinois at Chicago, 833 South Wood Street, Chicago, Illinois 60612, United States

7. Global Alliance for TB Drug Development, 40 Wall Street, New York 10005, United States

Funder

Drugs for Neglected Diseases Initiative

Global Alliance for TB Drug Development

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Reference59 articles.

1. Recent updates and perspectives on leishmaniasis

2. Epidemiology of visceral leishmaniasis

3. Investing to Overcome the Global Impact of Neglected Tropical Diseases: Third WHO Report on Neglected Tropical Diseases;World Health Organization:Geneva, Switzerland, 2015.

4. Visceral Leishmaniasis and HIV Coinfection in East Africa

5. An update on pharmacotherapy for leishmaniasis

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