Identification of a Novel 1,2,3,4-Tetrahydrobenzo[b][1,6]naphthyridine Analogue as a Potent Phosphodiesterase 5 Inhibitor with Improved Aqueous Solubility for the Treatment of Alzheimer’s Disease-Reference-Cited by-同舟云学术

Identification of a Novel 1,2,3,4-Tetrahydrobenzo[b][1,6]naphthyridine Analogue as a Potent Phosphodiesterase 5 Inhibitor with Improved Aqueous Solubility for the Treatment of Alzheimer’s Disease

Published:2017-10-23 Issue:21 Volume:60 Page:8858-8875
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Fiorito Jole¹,Vendome Jeremie²,Saeed Faisal¹,Staniszewski Agnieszka¹,Zhang Hong¹,Yan Shijun¹,Deng Shi-Xian³,Arancio Ottavio¹^ORCID,Landry Donald W.³

Affiliation:

1. Taub Institute for Research of Alzheimer’s Disease and the Aging Brain, Columbia University, 630 W 168th Street, New York, New York 10032, United States

2. Department of Systems Biology, Columbia University Medical Center, New York, New York 10032, United States

3. Department of Medicine, Columbia University, 650 W 168th Street, New York, New York 10032, United States

Funder

National Center for Advancing Translational Sciences at the National Institutes of Health

National Institute of Aging at the National Institutes of Health

National Institutes of Health

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.7b00979