Structure–Activity Relationship in Monosaccharide-Based Toll-Like Receptor 4 (TLR4) Antagonists

Author:

Facchini Fabio A.1ORCID,Zaffaroni Lenny1,Minotti Alberto1,Rapisarda Silvia1,Calabrese Valentina1,Forcella Matilde1,Fusi Paola1,Airoldi Cristina1ORCID,Ciaramelli Carlotta1,Billod Jean-Marc2,Schromm Andra B.3,Braun Harald4,Palmer Charys5,Beyaert Rudi4,Lapenta Fabio6,Jerala Roman6ORCID,Pirianov Grisha5,Martin-Santamaria Sonsoles2,Peri Francesco1ORCID

Affiliation:

1. Department of Biotechnology and Biosciences, University of Milano-Bicocca, Piazza della Scienza, 2, 20126 Milano, Italy

2. Department of Structural & Chemical Biology, Centro de Investigaciones Biologicas, CIB-CSIC, C/Ramiro de Maeztu, 9, 28040 Madrid, Spain

3. Division of Immunobiophysics, Research Center Borstel, Parkallee 1-40, 23845 Borstel, Germany

4. VIB-UGent Center for Inflammation Research, UGent Department for Biomedical Molecular Biology, Unit of Molecular Signal Transduction in Inflammation, Technologiepark 927, 9052 Ghent, Belgium

5. Anglia Ruskin Cambridge University, Cambridge CB1 1PT, U.K.

6. Department of Synthetic Biology and Immunology, Kemijski Institute, National Institute of Chemistry, Hajdrihova 19, SI-1000 Ljubljana, Slovenia

Funder

Horizon 2020

Ministerio de Econom?a y Competitividad

Ministero degli Affari Esteri e della Cooperazione Internazionale

Slovenian Research Agency

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

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