3-Hydroxy-N′-arylidenepropanehydrazonamides with Halo-Substituted Phenanthrene Scaffolds Cure P. berghei Infected Mice When Administered Perorally

Author:

Leven Michael1,Knaab Tanja C.1,Held Jana23,Duffy Sandra4,Meister Stephan5,Fischli Christoph67,Meitzner Diane8,Lehmann Ursula67,Lungerich Beate1,Kuna Krystina1,Stahlke Petra1,Delves Michael J.9,Buchholz Mirko8,Winzeler Elizabeth A.5ORCID,Avery Vicky M.4,Mordmüller Benjamin23,Wittlin Sergio67,Kurz Thomas1ORCID

Affiliation:

1. Institut für Pharmazeutische und Medizinische Chemie, Heinrich-Heine-Universität Düsseldorf, Universitätsstraße 1, 40225 Düsseldorf, Germany

2. Institut für Tropenmedizin, Eberhard Karls Universität Tübingen, Wilhelmstraße 27, 72074 Tübingen, Germany

3. Centre de Recherches Medicales de Lambaréné, B.P.: 242 Lambaréné, Gabon

4. Griffith Institute for Drug Discovery, Griffith University, Brisbane Innovation Park, Don Young Road, Nathan, Queensland 4111, Australia

5. Department of Pediatrics, School of Medicine, University of California, San Diego, La Jolla, California 92093, United States

6. Swiss Tropical and Public Health Institute, Socinstraße 57, 4002 Basel, Switzerland

7. University of Basel, CH-4003 Basel, Switzerland

8. Department of Drug Design and Target Validation, Fraunhofer-Institut für Zelltherapie und Immunologie, Weinbergweg 22, 06120 Halle (Saale), Germany

9. Cell and Molecular Biology, Department of Life Sciences, Imperial College, London SW7 2AZ, U.K.

Funder

Australian Research Council

Medicines for Malaria Venture

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

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