Discovery of Highly Potent and Selective Small-Molecule Reversible Factor D Inhibitors Demonstrating Alternative Complement Pathway Inhibition in Vivo-Reference-Cited by-同舟云学术

Discovery of Highly Potent and Selective Small-Molecule Reversible Factor D Inhibitors Demonstrating Alternative Complement Pathway Inhibition in Vivo

Published:2017-06-30 Issue:13 Volume:60 Page:5717-5735
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Lorthiois Edwige¹^ORCID,Anderson Karen²,Vulpetti Anna¹^ORCID,Rogel Olivier¹,Cumin Frederic¹,Ostermann Nils¹,Steinbacher Stefan³,Mac Sweeney Aengus¹,Delgado Omar²,Liao Sha-Mei²,Randl Stefan¹,Rüdisser Simon¹,Dussauge Solene¹,Fettis Kamal¹,Kieffer Laurence¹,de Erkenez Andrea²,Yang Louis²,Hartwieg Constanze¹,Argikar Upendra A.²^ORCID,La Bonte Laura R.²,Newton Ronald²,Kansara Viral²,Flohr Stefanie¹,Hommel Ulrich¹,Jaffee Bruce²,Maibaum Jürgen¹

Affiliation:

1. Novartis Pharma AG, Novartis Institutes for BioMedical Research, Novartis Campus, CH-4056 Basel, Switzerland

2. Novartis Pharma AG, Novartis Institutes for BioMedical Research, Cambridge, Massachusetts 02139, United States

3. Proteros Biostructures GmbH, D-82152 Planegg-Martinsried, Germany

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.7b00425

Reference40 articles.

1. Complement: a key system for immune surveillance and homeostasis