Targeted Antibiotic Delivery: Selective Siderophore Conjugation with Daptomycin Confers Potent Activity against Multidrug Resistant Acinetobacter baumannii Both in Vitro and in Vivo-Reference-Cited by-同舟云学术

Targeted Antibiotic Delivery: Selective Siderophore Conjugation with Daptomycin Confers Potent Activity against Multidrug Resistant Acinetobacter baumannii Both in Vitro and in Vivo

Published:2017-04-01 Issue:11 Volume:60 Page:4577-4583
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Ghosh Manuka¹,Miller Patricia A.¹²,Möllmann Ute¹,Claypool William D.³,Schroeder Valerie A.⁴,Wolter William R.⁴,Suckow Mark⁴,Yu Honglin⁵,Li Shuang⁵,Huang Weiqiang⁵,Zajicek Jaroslav²,Miller Marvin J.¹²^ORCID

Affiliation:

1. Hsiri Therapeutics, Innovation Park, 1400 East Angela Boulevard, South Bend, Indiana 46617, United States

2. Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana 46556, United States

3. Hsiri Therapeutics, LLC, Rosetree Corporate Center, 1400 N. Providence Road, Building 1, Suite 115S, Media, Pennsylvania 19063, United States

4. Frieman Life Sciences Center, University of Notre Dame, Notre Dame, Indiana 46556, United States

5. PracticaChem, 5 Lanyuan Road, Room D-603, Huayuan Industrial Park, Tianjin, 300384, China

Funder

U.S. Department of Defense

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

http://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.7b00102

Reference33 articles.

1. Prospects for new antibiotics: a molecule-centered perspective

2. Linezolid (ZYVOX), the First Member of a Completely New Class of Antibacterial Agents for Treatment of Serious Gram-Positive Infections

3. Development of daptomycin for Gram-positive infections

4. Investigational Agents for the Treatment of Gram-Negative Bacterial Infections: A Reality Check

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