The E15R Point Mutation in Scorpion Toxin Cn2 Uncouples Its Depressant and Excitatory Activities on Human NaV1.6
Author:
Affiliation:
1. Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland 4072, Australia
2. School of Pharmacy, The University of Queensland, Woolloongabba, Queensland 4102, Australia
Funder
Australian Research Council
Publisher
American Chemical Society (ACS)
Subject
Drug Discovery,Molecular Medicine
Link
https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.7b01609
Reference28 articles.
1. Voltage-gated sodium channels at 60: structure, function and pathophysiology
2. The hitchhiker’s guide to the voltage-gated sodium channel galaxy
3. Neurotoxins and Their Binding Areas on Voltage-Gated Sodium Channels
4. An animal model of oxaliplatin-induced cold allodynia reveals a crucial role for Nav1.6 in peripheral pain pathways
5. The TTX metabolite 4,9-anhydro-TTX is a highly specific blocker of the Nav1.6 voltage-dependent sodium channel
Cited by 10 articles. 订阅此论文施引文献 订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献
1. Voltage-gated sodium channels in cancer and their specific inhibitors;Pathology - Research and Practice;2023-11
2. Classical trigeminal neuralgia is associated with gephyrin and sodium voltage-gated channel alpha subunit 8;Frontiers in Dental Medicine;2023-01-30
3. Venom-derived pain-causing toxins: insights into sensory neuron function and pain mechanisms;Pain;2022-11
4. Low potency inhibition of NaV1.7 by externally applied QX-314 via a depolarizing shift in the voltage-dependence of activation;European Journal of Pharmacology;2022-06
5. Pain-related toxins in scorpion and spider venoms: a face to face with ion channels;Journal of Venomous Animals and Toxins including Tropical Diseases;2021
1.学者识别学者识别
2.学术分析学术分析
3.人才评估人才评估
"同舟云学术"是以全球学者为主线，采集、加工和组织学术论文而形成的新型学术文献查询和分析系统，可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容，当前同舟云学术共收录了国内外主流学术期刊6万余种，收集的期刊论文及会议论文总量共计约1.5亿篇，并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询！咨询电话：010-8811{复制后删除}0370
www.globalauthorid.com
TOP
Copyright © 2019-2024 北京同舟云网络信息技术有限公司 京公网安备11010802033243号 京ICP备18003416号-3