Vitamin D Analogues with a p-Hydroxyphenyl Group at the C25 Position: Crystal Structure of Vitamin D Receptor Ligand-Binding Domain Complexed with the Ligand Explains the Mechanism Underlying Full Antagonistic Action-Reference-Cited by-同舟云学术

Vitamin D Analogues with a p-Hydroxyphenyl Group at the C25 Position: Crystal Structure of Vitamin D Receptor Ligand-Binding Domain Complexed with the Ligand Explains the Mechanism Underlying Full Antagonistic Action

Published:2017-10-10 Issue:20 Volume:60 Page:8394-8406
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Kato Akira¹,Yamao Makiko¹,Hashihara Yuta¹,Ishida Hiroaki¹,Itoh Toshimasa¹,Yamamoto Keiko¹^ORCID

Affiliation:

1. Laboratory of Drug Design and Medicinal Chemistry, Showa Pharmaceutical University, 3-3165 Higashi-Tamagawagakuen, Machida, Tokyo 194-8543, Japan

Funder

Ministry of Education, Culture, Sports, Science and Technology

Japan Agency for Medical Research and Development

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.7b00819

Reference41 articles.

1. Regulation of target gene expression by the vitamin D receptor - an update on mechanisms

2. Structure of the full human RXR/VDR nuclear receptor heterodimer complex with its DR3 target DNA

3. Pharmaceutical Studies on Vitamin D Derivatives and Practical Syntheses of Six Commercially Available Vitamin D Derivatives That Contribute to Current Clinical Practice

4. Noncalcemic Actions of Vitamin D Receptor Ligands

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