Novel Aryl Substituted Pyrazoles as Small Molecule Inhibitors of Cytochrome P450 CYP121A1: Synthesis and Antimycobacterial Evaluation

Author:

Taban Ismail M.1,Elshihawy Hosam E. A. E.2,Torun Beyza13,Zucchini Benedetta14,Williamson Clare J.1,Altuwairigi Dania1,Ngu Adeline S. T.1,McLean Kirsty J.5,Levy Colin W.5,Sood Sakshi6,Marino Leonardo B.7,Munro Andrew W.5ORCID,de Carvalho Luiz Pedro S.6,Simons Claire1ORCID

Affiliation:

1. School of Pharmacy & Pharmaceutical Sciences, Cardiff University, King Edward VII Avenue, Cardiff CF10 3NB, U.K.

2. Department of Organic Chemistry, Faculty of Pharmacy, Suez Canal University, Ismalia, Egypt

3. Faculty of Pharmacy, Department of Pharmaceutical Chemistry, Ankara University, 06100 Tandogan, Ankara, Turkey

4. Department of Pharmaceutical Sciences, University of Perugia, Via del Liceo, 1-06123 Perugia, Italy

5. Manchester Institute of Biotechnology, School of Chemistry, The University of Manchester, 131 Princess Street, Manchester M1 7DN, U.K.

6. Mycobacterial Metabolism and Antibiotic Research Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K.

7. Faculty of Pharmaceutical Sciences, UNESP-Univ Estadual Paulista, Araraquara, São Paulo14801-902, Brazil

Funder

Medical Research Council

Conselho Nacional de Desenvolvimento Cient?fico e Tecnol?gico

Wellcome Trust

Funda??o de Amparo ? Pesquisa do Estado de S?o Paulo

Biotechnology and Biological Sciences Research Council

Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior

Cancer Research UK

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Reference23 articles.

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