Comprehensive Synthesis of Amino Acid-Derived Thiazole Peptidomimetic Analogues to Understand the Enigmatic Drug/Substrate-Binding Site of P-Glycoprotein-Reference-Cited by-同舟云学术

Comprehensive Synthesis of Amino Acid-Derived Thiazole Peptidomimetic Analogues to Understand the Enigmatic Drug/Substrate-Binding Site of P-Glycoprotein

Published:2018-01-23 Issue:3 Volume:61 Page:834-864
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Patel Bhargav A.¹,Abel Biebele²,Barbuti Anna Maria¹,Velagapudi Uday Kiran¹,Chen Zhe-Sheng¹,Ambudkar Suresh V.²^ORCID,Talele Tanaji T.¹^ORCID

Affiliation:

1. Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, St. John’s University, Queens, New York 11439, United States

2. Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, United States

Funder

National Cancer Institute

Department of Pharmaceutical Sciences, St. John?s University

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.7b01340

Reference58 articles.

1. Molecular mechanisms of drug resistance

2. Targeting multidrug resistance in cancer