Discovery of Potent and Orally Bioavailable Macrocyclic Peptide–Peptoid Hybrid CXCR7 Modulators-Reference-Cited by-同舟云学术

Discovery of Potent and Orally Bioavailable Macrocyclic Peptide–Peptoid Hybrid CXCR7 Modulators

Published:2017-10-30 Issue:23 Volume:60 Page:9653-9663
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Boehm Markus¹^ORCID,Beaumont Kevin¹,Jones Rhys¹,Kalgutkar Amit S.¹,Zhang Liying¹,Atkinson Karen²,Bai Guoyun²,Brown Janice A.²,Eng Heather²,Goetz Gilles H.²^ORCID,Holder Brian R.²,Khunte Bhagyashree²,Lazzaro Sarah²,Limberakis Chris²,Ryu Sangwoo²,Shapiro Michael J.²,Tylaska Laurie²,Yan Jiangli²,Turner Rushia³,Leung Siegfried S. F.⁴⁵,Ramaseshan Mahesh⁵,Price David A.¹,Liras Spiros¹,Jacobson Matthew P.⁴^ORCID,Earp David J.⁵,Lokey R. Scott³^ORCID,Mathiowetz Alan M.¹,Menhaji-Klotz Elnaz¹^ORCID

Affiliation:

1. Pfizer Worldwide Research & Development, Cambridge, Massachusetts 02139, United States

2. Pfizer Worldwide Research & Development, Groton, Connecticut 06340, United States

3. Chemistry and Biochemistry, University of California, Santa Cruz, California 95064, United States

4. Department of Pharmaceutical Chemistry, University of California, San Francisco, California 94158, United States

5. Circle Pharma, South San Francisco, California 94080, United States

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

http://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.7b01028

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2. Impaired B-lymphopoiesis, myelopoiesis, and derailed cerebellar neuron migration in CXCR4- and SDF-1-deficient mice

3. The HIV coreceptors CXCR4 and CCR5 are differentially expressed and regulated on human T lymphocytes

4. -arrestin- but not G protein-mediated signaling by the "decoy" receptor CXCR7

5. CXCR7 heterodimerizes with CXCR4 and regulates CXCL12-mediated G protein signaling

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