Synthesis, Binding Mode, and Antihyperglycemic Activity of Potent and Selective (5-Imidazol-2-yl-4-phenylpyrimidin-2-yl)[2-(2-pyridylamino)ethyl]amine Inhibitors of Glycogen Synthase Kinase 3-Reference-Cited by-同舟云学术

Synthesis, Binding Mode, and Antihyperglycemic Activity of Potent and Selective (5-Imidazol-2-yl-4-phenylpyrimidin-2-yl)[2-(2-pyridylamino)ethyl]amine Inhibitors of Glycogen Synthase Kinase 3

Published:2017-10-10 Issue:20 Volume:60 Page:8482-8514
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Wagman Allan S.¹,Boyce Rustum S.¹,Brown Sean P.¹,Fang Eric¹,Goff Dane¹,Jansen Johanna M.¹,Le Vincent P.¹,Levine Barry H.¹,Ng Simon C.¹,Ni Zhi-Jie¹,Nuss John M.¹,Pfister Keith B.¹,Ramurthy Savithri¹^ORCID,Renhowe Paul A.¹,Ring David B.¹,Shu Wei¹,Subramanian Sharadha¹,Zhou Xiaohui A.¹,Shafer Cynthia M.¹,Harrison Stephen D.¹,Johnson Kirk W.¹,Bussiere Dirksen E.¹^ORCID

Affiliation:

1. Global Discovery Chemistry, Novartis Institutes for BioMedical Research, 5300 Chiron Way, Emeryville, California 94608, United States

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.7b00922

Reference104 articles.

1. Glycemic Control With Diet, Sulfonylurea, Metformin, or Insulin in Patients With Type 2 Diabetes MellitusProgressive Requirement for Multiple Therapies (UKPDS 49)

2. Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33)

3. Managing Type 2 Diabetes Mellitus in Patients with Obesity

4. Glucagon therapeutics: Dawn of a new era for diabetes care

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