Structure Based Design of a Grp94-Selective Inhibitor: Exploiting a Key Residue in Grp94 To Optimize Paralog-Selective Binding-Reference-Cited by-同舟云学术

Structure Based Design of a Grp94-Selective Inhibitor: Exploiting a Key Residue in Grp94 To Optimize Paralog-Selective Binding

Author:

Que Nanette L. S.¹^ORCID,Crowley Vincent M.²,Duerfeldt Adam S.²^ORCID,Zhao Jinbo²,Kent Caitlin N.³,Blagg Brian S. J.³^ORCID,Gewirth Daniel T.¹⁴^ORCID

Affiliation:

1. Hauptman-Woodward Medical Research Institute, Buffalo, New York 14203, United States

2. Department of Medicinal Chemistry, The University of Kansas, Lawrence, Kansas 66045, United States

3. Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana 46556, United States

4. Department of Structural Biology, University at Buffalo, Buffalo, New York 14203, United States

Funder

U.S. Department of Health and Human Services

Mae Stone Goode Trust, University of Buffalo

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

Reference48 articles.

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