Discovery and Optimization of Chromeno[2,3-c]pyrrol-9(2H)-ones as Novel Selective and Orally Bioavailable Phosphodiesterase 5 Inhibitors for the Treatment of Pulmonary Arterial Hypertension-Reference-Cited by-同舟云学术

Discovery and Optimization of Chromeno[2,3-c]pyrrol-9(2H)-ones as Novel Selective and Orally Bioavailable Phosphodiesterase 5 Inhibitors for the Treatment of Pulmonary Arterial Hypertension

Published:2017-07-25 Issue:15 Volume:60 Page:6622-6637
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Wu Deyan¹,Zhang Tianhua¹,Chen Yiping¹,Huang Yadan¹,Geng Haiju¹,Yu Yanfa¹,Zhang Chen¹,Lai Zengwei¹,Wu Yinuo¹,Guo Xiaolei²,Chen Jianwen¹,Luo Hai-Bin¹³^ORCID

Affiliation:

1. School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou 510006, P. R. China

2. Infinitus (China) Co. Ltd., Guangzhou 510663, China

3. Collaborative Innovation Center of High Performance Computing, National University of Defense Technology, Changsha 410073, China

Funder

National Natural Science Foundation of China

Natural Science Foundation of Guangdong Province

Guangdong Province

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine