An Efficient Buchwald–Hartwig/Reductive Cyclization for the Scaffold Diversification of Halogenated Phenazines: Potent Antibacterial Targeting, Biofilm Eradication, and Prodrug Exploration-Reference-Cited by-同舟云学术

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An Efficient Buchwald–Hartwig/Reductive Cyclization for the Scaffold Diversification of Halogenated Phenazines: Potent Antibacterial Targeting, Biofilm Eradication, and Prodrug Exploration

Published:2018-04-11 Issue:9 Volume:61 Page:3962-3983
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Garrison Aaron T.¹,Abouelhassan Yasmeen¹,Kallifidas Dimitris¹,Tan Hao²,Kim Young S.²^ORCID,Jin Shouguang²,Luesch Hendrik¹^ORCID,Huigens Robert W.¹

Affiliation:

1. Department of Medicinal Chemistry, Center for Natural Products, Drug Discovery and Development (CNPD3), College of Pharmacy, University of Florida, Gainesville, Florida 32610, United States

2. Department of Molecular Genetics & Microbiology, College of Medicine, University of Florida, Gainesville, Florida 32610, United States

Funder

University of Florida

Emerging Pathogens Institute, University of Florida

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.7b01903

Reference57 articles.

1. Targeting virulence: a new paradigm for antimicrobial therapy

2. Bacterial Persister Cell Formation and Dormancy

3. Combatting bacterial persister cells

4. Persister Cells

5. The Role of Biofilms: Are We Hitting the Right Target?

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