A Kinome-Wide Selective Radiolabeled TrkB/C Inhibitor for in Vitro and in Vivo Neuroimaging: Synthesis, Preclinical Evaluation, and First-in-Human

Author:

Bernard-Gauthier Vadim1ORCID,Bailey Justin J.1,Mossine Andrew V.2,Lindner Simon3,Vomacka Lena3,Aliaga Arturo4,Shao Xia2,Quesada Carole A.2,Sherman Phillip2,Mahringer Anne5,Kostikov Alexey6,Grand’Maison Marilyn7,Rosa-Neto Pedro4,Soucy Jean-Paul8,Thiel Alexander69,Kaplan David R.1011,Fricker Gert5,Wängler Björn12,Bartenstein Peter3,Schirrmacher Ralf1,Scott Peter J. H.213

Affiliation:

1. Department of Oncology, Division of Oncological Imaging, University of Alberta, Edmonton, Alberta T6G 2R3, Canada

2. Division of Nuclear Medicine, Department of Radiology, The University of Michigan Medical School, Ann Arbor, Michigan 48109, United States

3. Department of Nuclear Medicine, Ludwig-Maximilians-University of Munich, Marchioninistrasse 15, Munich 81377, Germany

4. Translational Neuroimaging Laboratory, McGill Centre for Studies in Aging, Douglas Mental Health University Institute, 6875 Boulevard LaSalle, Montreal, Quebec H4H 1R3, Canada

5. Institute of Pharmacy and Molecular Biotechnology, University of Heidelberg, Heidelberg 69120, Germany

6. McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, 3801 University Street, Montreal, Quebec H3A 2B4, Canada

7. Biospective Inc., 6100 Avenue Royalmount, Montreal, Quebec H4P 2R2, Canada

8. Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, 3801 University Street, Montreal, Quebec H3A 2B4, Canada

9. Jewish General Hospital, Lady Davis Institute, Montreal, Quebec HT3 1E2, Canada

10. Program in Neurosciences and Mental Health, Hospital for Sick Children, Toronto, Ontario M5G 0A4, Canada

11. Department of Molecular Genetics, University of Toronto, Toronto, Ontario M5S1A8, Canada

12. Molecular Imaging and Radiochemistry, Department of Clinical Radiology and Nuclear Medicine, Medical Faculty Mannheim of Heidelberg University, Theodor-Kutzer-Ufer 1-3, Mannheim 68167, Germany

13. The Interdepartmental Program in Medicinal Chemistry, University of Michigan, Ann Arbor, Michigan 48109, United States

Funder

Canada Foundation for Innovation

National Institute of Biomedical Imaging and Bioengineering

U.S. Department of Energy

Natural Sciences and Engineering Research Council of Canada

Cancer Research Society

Weston Brain Institute

C7 Council

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3